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KMID : 0903519760190020070
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
1976 Volume.19 No. 2 p.70 ~ p.74
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The Study of Iodine Metabolism IN VIVO Utilizing Ⅰ- 131
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Abstract
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In order to study the mechanism of biosynthesis of thyroid hormones, radioactive iodine was injected into the rats and thyroid glands were removed. Iodine compounds hydrolyzed by pancreatin viokase were separated by paper chromatography and analyzed by radioautography. Radioautograms showed that the uptake of iodine starts immediately and forms diiodotyrosine through monoiodotyrosine.
Evidence supported the possibility that diiodotyrosine is a precursor of thyrosine and triiodothyronine is a degradation product of thyroxine.
The rat administered propylthiouracil showed inorganic iodine concentration activity, while the binding activity was prevented.
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